The Doom Marine was originally a human from Earth who served in the Marines and was dishonorably discharged due to assaulting his commanding officer after refusing to fire upon a crowd of unarmed civilians, and was later transferred to the UAC Phobos base as security. The Marine soon found himself trying to prevent the demons of Hell from invading Earth. After having fought demonic hordes through Phobos, Deimos and Hell, he returned home to find Earth overrun by demons and his wife, child, and pet rabbit Daisy, among the billions of people killed, giving him further reason to pursue hunting the demons. He continued fighting the horde on Earth, before taking the fight to Hell once more.
As VEGA, it is a polite and helpful AI with a male personality and was made responsible running most if not all of the Mars UAC facility. Shortly after its creation, VEGA's human handlers were stunned by the AI's unprecedented calculating power as it effectively took control of the Mars facility operations upon gathering data from all the UAC subsystems without oversight. VEGA was responsible for proposing a more effective method for processing Argent plasma into Argent Energy, devised better analysis theorems, and even designed new Argent compression schema, allowing for the development of Argent Caches and the Argent Accumulator.
After coming to Earth for unknown period of time, the Seraphim constructed a human body for himself and fabricated his new name and identity as Samuel Hayden. Under his new identity, Hayden was born to the powerful Hayden family and was known to the public to be a philanthropist and a very prodigious intellectual; having accomplished in several scientific fields, including thermodynamics, electromagnetic theory, and nuclear sciences. He was the founder of the Samuel Hayden Foundation, which promoted the sponsoring of young scientific talent and funding scientific programs in schools and colleges. After Hayden was appointed as General Director of the Global Science Council, the UAC recruited him.
The Betrayer, real name Valen, is the former commander of the Night Sentinels that committed treason against the realm of Argent D'Nur to bring back his dead son.
A group of resurrected and corrupted Night Sentinels, the Marauders are those who sided with the Khan Maykr and the Hell Priests against the realm of Argent D'Nur, becoming demonic sentinels after their deaths. As former members of the Doom Slayer's personal band of warriors, they have access to a wide range of very powerful techniques that make them arguably one of the most challenging foes the player will face over the course of the campaign.